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Pharmacodynamics and kinetics of omeprazole MUPS 20 mg and pantoprazole 40 mg during repeated oral administration in Helicobacter pylori ‐negative subjects
Author(s) -
Geus W. P.,
Mathôt R. A. A.,
Mulder P. G. H.,
Lamers C. B. H. W.
Publication year - 2000
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2000.00806.x
Subject(s) - omeprazole , pantoprazole , cmax , medicine , bioavailability , crossover study , pharmacokinetics , pharmacology , pharmacodynamics , helicobacter pylori , proton pump inhibitor , oral administration , gastroenterology , placebo , alternative medicine , pathology
Background: Omeprazole has become available in a tablet formulation, a Multiple Unit Pellet System (MUPS) containing a large number of small individually enteric‐coated micropellets. Aim: To compare the acid‐inhibitory effect of omeprazole MUPS 20 mg with pantoprazole 40 mg and to describe the pharmacokinetics of both drugs following administration on day 1 and day 6. Methods: Randomized, two‐way crossover study. Sixteen Helicobacter pylori ‐negative healthy subjects, whose gastric acidity fell below pH 4 for 70% of a 24‐h baseline period were included. Intragastric pH was measured continuously. Results: On day 1 both drugs significantly raised median 24‐h gastric pH compared to baseline. Median pH and percentages of time above pH 3 and 4 on day 1 and day 6 of administration were not significantly different, with the exception of median daytime pH on day 6, which was significantly higher with omeprazole (4.65 vs. 4.05). AUC and C max of omeprazole were significantly increased on day 6. AUC and C max of pantoprazole were not significantly increased. Conclusions: No significant difference in acid‐inhibitory effect on day 1. On day 6 median daytime pH was significantly higher with omeprazole MUPS, but the percentages of time spent above pH 3 and 4 were not significantly different. The significant increase in bioavailability of omeprazole may contribute to the increased effect on day 6.