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Efficacy of sucralfate for Helicobacter pylori eradication triple therapy in comparison with a lansoprazole‐based regimen
Author(s) -
• Adachi,
Ishihara,
Y. Hashimoto,
Hirakawa,
Niigaki,
Takashima,
Kaji,
; Kawamura,
; Sato,
Okuyama,
Kenji Watanabe,
; Kinoshita
Publication year - 2000
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2000.00791.x
Subject(s) - lansoprazole , sucralfate , medicine , regimen , clarithromycin , gastroenterology , helicobacter pylori , urea breath test , breath test , amoxicillin , antibiotics , helicobacter pylori infection , microbiology and biotechnology , biology
Background: Sucralfate has an inhibitory action against Helicobacter pylori and enhances the anti‐ H. pylori activity of antimicrobials. Aim: To evaluate the efficacy and safety of sucralfate‐based eradication therapy for H. pylori infection, compared with that based on lansoprazole, in a randomized multicentre study. Subjects and methods: The subjects were 150 H. pylori ‐positive patients. They were randomly assigned to one of two regimens for 2 weeks: sucralfate 1 g t.d.s., amoxycillin 500 mg t.d.s., and clarithromycin 400 mg b.d. (SAC regimen: 75 patients); or lansoprazole 30 mg o.m. with the same antimicrobial medications (LAC regimen: 75 patients). Cure of infection was assessed by a 13 C urea breath test 1 month after completion of treatment. Results: Eight patients (four in the SAC group and four in LAC group) could not continue therapy because of severe diarrhoea, and three did not take the 13 C urea breath test after therapy. Cure rates for intention‐to‐treat, all‐patients‐treated, and per protocol analysis in the SAC group were 80%, 83%, and 88%, respectively, and those in the LAC group were 87%, 87%, and 92%, respectively. There were no significant differences in cure rate or adverse effects between the two regimens. Conclusion: Sucralfate in combination with amoxycillin and clarithromycin is as effective as lansoprazole‐based eradication therapy for H. pylori .