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Nasogastric lansoprazole is effective in suppressing gastric acid secretion in critically ill patients
Author(s) -
Wan-Jan Tsai,
SekKwong Poon,
Hsing-Kuen Yu,
Chi-Sen Chang,
Hong Zen Yeh,
ChungWang Ko,
G H Chen
Publication year - 2000
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.2000.00680.x
Subject(s) - lansoprazole , medicine , critically ill , gastric acid , gastroenterology , stomach , omeprazole
Aim: To evaluate the effect of nasogastric lansoprazole on acid suppression in critically ill patients. Methods: Patients were eligible for the study if they had a nasogastric tube in place and had not received acid‐suppressive agents for 3 days prior to enrolment into the study. Patients with active gastrointestinal bleeding or a baseline gastric pH > 4.0 were excluded. Patients served as their own controls during a 24 h lead‐in period. Lansoprazole 30 mg was administered once daily with water through a nasogastric tube for 2 days. Intragastric pH was measured by continuous 24 h pH‐metry for 3 days. Results: Fifteen patients were enrolled into the study. The baseline median 24 h intragastric pH was 2.25 ± 1.01, and increased to 6.70 ± 0.82 ( P= 0.001) after 2 days of lansoprazole. Mean percentage of time intragastric pH was ≥ 4.0 was 25 ± 13% at baseline, and increased to 84 ± 14% ( P =0.001) after 2 days of lansoprazole. Conclusions: Nasogastric lansoprazole 30 mg daily is effective in suppressing gastric acid secretion in critically ill patients.