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Low‐dose lansoprazole provides greater relief of heartburn and epigastric pain than low‐dose omeprazole in patients with acid‐related dyspepsia
Author(s) -
Roger Jones,
Sarah Crouch
Publication year - 1999
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1999.00455.x
Subject(s) - heartburn , lansoprazole , medicine , epigastric pain , omeprazole , gastroenterology , reflux , disease , vomiting
Aim : To compare the relative efficacies of lansoprazole 15 mg o.m. and omeprazole 10 mg o.m. in relieving heartburn and epigastric pain in patients with acid‐related dyspepsia. In addition, the study compared the safety profiles of the two treatments. Methods : This double‐blind, parallel group, randomised, multicentre study was conducted in 52 general practices in the UK. A total of 609 patients was recruited, 562 of whom were eligible for inclusion in the intention‐to‐treat analysis. All of the patients had experienced at least mild heartburn or mild epigastric pain persistently on at least 4 of the previous 7 days; patients with severe symptoms were excluded. 283 patients received lansoprazole 15 mg and 279 received omeprazole 10 mg, both for 4 weeks. The main efficacy measure was relief of symptoms, based on physician assessments. Results : In the intention‐to‐treat population, a complete relief of overall primary symptoms of dyspepsia was achieved after 2 weeks in 53% of patients receiving lansoprazole and in 41% of patients receiving omeprazole ( P = 0.007). After 4 weeks, 59% of the lansoprazole group and 51% of the omeprazole group had achieved complete symptom relief ( P = 0.078). Antacids were taken for additional relief of symptoms in fewer patients given lansoprazole compared to the omeprazole group in the third and fourth weeks ( P = 0.035) and also significantly fewer antacids were taken by patients in the lansoprazole group compared with patients in the omeprazole group ( P = 0.033). The proportion of patients reporting adverse events was similar in both groups. Conclusion : Low‐dose lansoprazole is more effective than low‐dose omeprazole in the treatment of patients with mild heartburn or epigastric pain in general practice.