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Review article: rabeprazole’s profile in patients with gastrointestinal diseases
Author(s) -
Mark D. Humphries,
Barth
Publication year - 1999
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1999.00036.x
Subject(s) - rabeprazole , medicine , tolerability , gerd , proton pump inhibitor , omeprazole , gastroenterology , dosing , cyp2c19 , regimen , clinical trial , heartburn , disease , pharmacology , reflux , adverse effect , cytochrome p450 , metabolism
The selection of agents to treat patients with acid‐related gastrointestinal diseases requires knowledge of their efficacy, tolerability, and ease of dosing among individuals with differing disease severities and other baseline characteristics. The efficacy and favourable benefit–risk profile of rabeprazole, a new proton pump inhibitor, has been demonstrated in controlled clinical trials of patients with gastro‐oesophageal reflux disease (GERD), duodenal ulcers, and gastric ulcers. In comparative trials, rabeprazole is at least as effective as omeprazole for the treatment of GERD, duodenal ulcers, and gastric ulcers, and it is superior to histamine 2 ‐receptor antagonists for the treatment of GERD and duodenal ulcers. Its once‐daily dosing regimen and low potential for interaction with drugs metabolized by the cytochrome P450 system make it a particularly attractive option for the treatment of acid‐related diseases among older individuals. Rabeprazole is likely to be a valuable new addition to its class in treating patients with acid‐related gastrointestinal diseases given its efficacy in acid suppression, high healing rates, rapid symptom relief, and convenient dosing.