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Effects of somatostatin on proximal gastric motor function and visceral perception
Author(s) -
Mearadji,
Straathof,
Biemond,
Lamers,
Masclee
Publication year - 1998
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1998.00402.x
Subject(s) - medicine , somatostatin , motor function , function (biology) , perception , neuroscience , physical medicine and rehabilitation , microbiology and biotechnology , psychology , biology
Background: Somatostatin affects gastrointestinal motility and secretion and visceral sensation, but little is known about its effects on the proximal stomach. Aim: To evaluate the effects of somatostatin on proximal gastric motor function and perception of symptoms. Methods: Six healthy subjects participated in two experiments performed in random order during continuous intravenous infusion of saline or somatostatin (250 μ g/h). Proximal gastric motor function was evaluated using a barostat. We performed pressure and volume distensions and a barostat procedure (minimal distending pressure + 2 mmHg). Symptoms were evaluated at regular intervals using visual analogue scales (VAS). Results: Neither minimal distending pressure nor gastric fundal tone were significantly different between somatostatin and saline. Pressure–volume curves during distensions were not influenced by somatostatin. However, phasic volume waves were significantly ( P < 0.001) reduced by somatostatin, and somatostatin significantly ( P < 0.05) reduced symptom perception of fullness and abdominal pressure during stepwise distensions. Conclusions: Continuous infusion of somatostatin does not influence gastric compliance but it inhibits phasic volume waves and significantly reduces visceral perception.