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Pantoprazole 20 mg is effective for relief of symptoms and healing of lesions in mild reflux oesophagitis
Author(s) -
Dettmer A.,
Vogt R.,
Sielaff F.,
Lühmann R.,
Schneider A.,
Fischer R.
Publication year - 1998
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1998.00381.x
Subject(s) - pantoprazole , medicine , ranitidine , heartburn , gerd , gastroenterology , proton pump inhibitor , reflux , esophagitis , esophageal disease , omeprazole , disease , esophagus
Aim: To investigate the efficacy of a low dose of pantoprazole, a gastric proton pump inhibitor, for the relief of symptoms and healing of lesions in mild gastro‐oesophageal reflux disease (GERD), and to compare it with the efficacy of ranitidine. Methods: Patients with endoscopically established GERD (Stage I, Savary–Miller classification) were enrolled into a randomized, double‐blind, parallel‐group and multicentre study (intention‐to‐treat n = 209, age range 19–82 years). They were treated once daily with oral pantoprazole 20 mg or ranitidine 300 mg, for up to 8 weeks. End‐point parameters included relief of symptoms (heartburn, acid regurgitation, pain on swallowing) and the healing of GERD lesions. Relief from symptoms was assessed after 2 and 4 weeks, and endoscopically confirmed healing of lesions after 4 and 8 weeks. Results: The proportion of patients reporting complete relief from symptoms after 2 weeks was greater in the pantoprazole than in the ranitidine group (69 vs. 48%, P < 0.01), with further improvements seen in the pantoprazole group after 4 weeks (80 vs. 65%, P < 0.05, Cochran–Mantel/Haenszel test). Healing of lesions was confirmed in 70/87 (80%) patients after 4 weeks (pantoprazole group), as compared with 55/86 (64%) patients (ranitidine group) ( P < 0.05, per protocol population); after 8 weeks the respective results were 78/87 (90%) and 63/86 (73%) patients ( P < 0.01). Both study medications were well tolerated. Conclusion: Low‐dose pantoprazole (20 mg) is clinically superior to ranitidine (300 mg) in providing fast relief from symptoms and healing of lesions in patients with mild GERD.