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Ranitidine bismuth citrate with either clarithromycin 1 g/day or 1.5 g/day is equally effective in the eradication of H. pylori and healing of duodenal ulcer
Author(s) -
G Dobrilla,
G. Di Matteo,
M Dodero,
A. Fratton,
Gaetano Iaquinto,
Pietro Loriga,
Santino Marchi,
L. Marzio,
Rosangela Muratori,
David L. Pacini,
A. Saggioro,
Vincenzo Savarino,
P Spinelli,
Giuseppe Zamboni,
Paul Fina,
R. Tosatto,
A. Olivieri
Publication year - 1998
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1998.00279.x
Subject(s) - clarithromycin , medicine , gastroenterology , ranitidine hydrochloride , helicobacter pylori , ranitidine , omeprazole , histology , duodenal ulcer , group b , adverse effect , spirillaceae , gastritis
Background: No randomized double‐blind studies have been performed to compare clarithromycin 1 g/day with higher doses of the macrolide (1.5 g/day) when combined with ranitidine bismuth citrate (RBC). Aim: To compare H. pylori eradication and ulcer healing rates of RBC 400 mg b.d. for 4 weeks combined for the first 2 weeks either with clarithromycin 500 mg b.d. (Group A) or clarithromycin 500 mg t.d.s. (Group B). Methods: Two hundred and seventy‐three patients with H. pylori ‐positive active duodenal ulcer were included . H. pylori infection was detected by CLO‐test and histology on antral and corpus biopsies before and at least 4 weeks after the end of therapy. Eradication was assumed if both CLO‐test and histology results were negative for H. pylori . Results: Eradication/healing rates according to intention‐to‐treat and per protocol analysis were 76/82% and 87/92% for Group A and 78/85% and 88/95% for Group B, respectively ( P = N.S.). Adverse events were reported by 7% and 12% of patients in Groups A and B, respectively, and they were generally mild. Conclusions: RBC in co‐prescription with clarithromycin 500 mg b.d. is as effective as RBC plus clarithromycin 500 t.d.s. in eradicating H. pylori and healing duodenal ulcers.