Premium
Effects of an isotonic oral rehydration solution, enriched with glutamine, on fluid and sodium absorption in patients with short‐bowel syndrome
Author(s) -
BEAUGERIE L.,
CARBONNEL F.,
HECKETSWEILER B.,
DÉCHELOTTE P.,
GENDRE J.P.,
COSNES J.
Publication year - 1997
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1997.t01-1-00201.x
Subject(s) - glutamine , sodium , osmole , chemistry , absorption (acoustics) , chromatography , medicine , biochemistry , amino acid , materials science , organic chemistry , composite material
Aim : To compare the effects of a standard oral rehydration solution with a polymeric glucose isotonic solution enriched with glutamine on water and sodium absorption in the short bowel. Methods : Six patients with high jejunostomy were tested in a random order on 2 consecutive days with the standard solution (20 g/L glucose, 94 mmol/L sodium, 292 mOsm/kg osmolality) and a solution containing maltodextrins (18 g/L Glucidex 12; hydrolysis of 18 g of Glucidex 12 yields 20 g glucose) enriched with 14.6 g/L of glutamine (94 mmol/L sodium, 282 mOsm/kg osmolality). Solutions were administered via a naso‐gastric tube at a rate of 2 mL/min. Jejunal effluent for each solution was collected during an 8‐h period, after a 14‐h equilibrium period. Results : The net 8‐h fluid absorption was not significantly different between the standard solution and the solution with glutamine (333 ± 195 and 213 ± 251 mL, respectively (mean ± S.E.M.)). Net sodium absorption was higher for the standard solution than for the solution with glutamine (15 ± 15 vs. 2 ± 20 mmol, P < 0.05). The rate of glucose absorption was not different between the solutions. Conclusion : The replacement of glucose by maltodextrins and the addition of glutamine to the standard oral rehydration solution, without changing its sodium content or osmolality, results in a reduction of sodium absorption in the short‐bowel syndrome.