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A one‐week quadruple eradication regimen for Helicobacter pylori in routine clinical practice
Author(s) -
VAUTIER G.,
SCOTT B. B.
Publication year - 1997
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1997.87259000.x
Subject(s) - medicine , omeprazole , regimen , metronidazole , helicobacter pylori , gastroenterology , nausea , breath test , urea breath test , tetracycline , surgery , antibiotics , helicobacter pylori infection , microbiology and biotechnology , biology
Background : The addition of omeprazole to 1 week of standard triple therapy (tripotassium dicitrato bismuthate, tetracycline and metronidazole) has given a 98% eradication rate in 54 patients at 4–6 weeks in a research setting. We report the result of a similar 1‐week regimen in 52 patients in routine clinical practice assessed at a mean of 8 months. Methods : Fifty‐two patients with peptic ulcer disease and antral biopsies containing Helicobacter pylori sensitive to metronidazole were given a 7‐day course of treatment: omeprazole 20 mg b.d., tetracycline 500 mg q.d.s. and tripotassium dictitrato bismuthate chelate tablets 120 mg q.d.s., with metronidazole 400 mg five times daily for the last 3 days only. Completeness of eradication was assessed by a 13 C‐urea breath test at 4–26 months (mean 8 months). Results : Forty‐eight patients (92%) had a negative breath test. Three patients vomited on the last day of the course, otherwise the treatment was well tolerated with the expected minor side‐effects of tongue discoloration, nausea and unpleasant taste. Conclusions : The efficacy of a modified 1‐week standard triple therapy with omeprazole is confirmed and shown to be almost as effective in routine clinical practice as a similar regimen in a research setting.