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Lansoprazole versus omeprazole: influence on meal‐stimulated gastric acid secretion
Author(s) -
DAMMANN H. G.,
FUCHS W.,
RICHTER G.,
BURKHARDT F.,
WOLF N.,
WALTER Th. A.
Publication year - 1997
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1997.157332000.x
Subject(s) - lansoprazole , omeprazole , placebo , pharmacology , crossover study , proton pump inhibitor , gastric acid , medicine , meal , chemistry , potency , secretion , biochemistry , alternative medicine , pathology , in vitro
Aims: To investigate, by means of meal‐stimulated acid secretion, the extent to which differences in plasma half‐life, bioavailability and the recommended therapeutic dose can influence the antisecretory potency of lansoprazole and omeprazole. Methods: In this double‐blind, placebo‐controlled, crossover study, 10 healthy male volunteers received 15 mg or 30 mg lansoprazole, 20 mg or 40 mg omeprazole or placebo for 5 days, in a randomized order. Meal‐stimulated acid secretion was determined by means of a homogenized test meal and intragastric titration. Results: On day 1, meal‐stimulated acid secretion was decreased by 35% and 45% after administration of 15 mg or 30 mg lansoprazole, and by 16% and 42% after 20 mg or 40 mg omeprazole. After 3 and 5 days of dosing the decreases were 53% and 48% with 15 mg lansoprazole, 82% and 82% with 30 mg lansoprazole, 43% and 39% with 20 mg omeprazole, and 76% and 83% with 40 mg omeprazole. At all measuring points during the 5‐day dosing periods, lansoprazole 15 mg and 30 mg proved superior to 20 mg omeprazole in inhibiting meal‐stimulated gastric acid secretion, but the differences were only statistically significant for the lansoprazole 30 mg dose. 30 mg lansoprazole and 40 mg omeprazole proved equipotent. On day 1 only 30 mg lansoprazole was significantly better than placebo. Conclusion: This study demonstrated the following order of antisecretory potency: 30 mg lansoprazole=40 mg omeprazole>15 mg lansoprazole≈20 mg omeprazole.