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Efficacy and tolerance of mesalazine suppositories vs. hydrocortisone foam in proctitis
Author(s) -
LUCIDARME D.,
MARTEAU P.,
FOUCAULT M.,
VAUTRIN B.,
FILOCHE B.
Publication year - 1997
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1997.126297000.x
Subject(s) - mesalazine , medicine , suppository , proctitis , hydrocortisone , gastroenterology , endoscopy , rectal administration , antipyretic , ulcerative colitis , anesthesia , pharmacology , disease , analgesic
Background : Topical treatments with steroids or mesalazine are the most effective treatments for idiopathic proctitis. Aim : to compare the efficacy and tolerance of mesalazine suppositories vs. hydrocortisone acetate foam in the treatment of acute proctitis. Patients and methods : 242 patients with active idiopathic proctitis were randomized to receive once daily either one Pentasa suppository (mesalazine 1 g) or 100 mg hydrocortisone (Colofoam) for 14–21 days (until remission). Disease activity and tolerance of the treatments were assessed using a daily questionnaire, by physician assessment, and endoscopy score. Results : Both treatments induced a significant reduction in disease activity. Mesalazine suppositories were significantly more effective than hydrocortisone on rectal blood loss ( P =0.002) and mucus ( P =0.02) parameters, and on the degree of the decrease in endoscopy score ( P =0.02). No significant difference was observed between treatments concerning histology or tolerance. Conclusion : Mesalazine suppositories were as well‐tolerated as hydrocortisone foam, but were more effective for some parameters of disease activity.