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Comparison of ranitidine and lansoprazole in short‐term low‐dose triple therapy for Helicobacter pylori infection
Author(s) -
Kihira K.,
Satoh K.,
Saifuku K.,
Taniguchi Y.,
Takimoto T.,
Yamamoto H.,
Ido K.,
Yoshida Y.,
Kimura K.
Publication year - 1997
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1997.00186.x
Subject(s) - lansoprazole , metronidazole , medicine , helicobacter pylori , ranitidine , clarithromycin , gastroenterology , proton pump inhibitor , adverse effect , gastritis , pharmacology , antibiotics , microbiology and biotechnology , biology
Aim: To evaluate the efficacy and safety of two 1‐week low‐dose triple‐therapy drug regimens involving antisecretory drugs for Helicobacter pylori infection, 99␣patients with H. pylori infection were treated with either lansoprazole or ranitidine used together with clarithromycin and metronidazole. Methods: The drug combination and administration periods in the proton pump inhibitor group were lansoprazole 30 mg o.m., clarithromycin 200 mg b.d. and metronidazole 250 mg b.d., all given for 7 days (LCM group). The ranitidine group received ranitidine 150 mg b.d., clarithromycin 200 mg b.d. and metronidazole 250 mg b.d. also for 7 days (RCM group). The presence or absence of H. pylori was determined from gastric biopsy specimens taken from both the antrum and the body, by smear, culture and tissue section (Giemsa stain). Cure was defined as failure to find evidence of H. pylori infection 4 weeks after antimicrobial therapy had ended. Results: The cure of H. pylori infection was 88% in the LCM group (44 of 50; 95% confidence interval (CI) = 79–97%) and 92% in the RCM group (45 of 49; 95% CI = 84–99%). The incidence of adverse events was 16% and 18% for the two groups, respectively. Conclusions: No significant differences in cure rate and safety profiles were noted between the two regimens, suggesting that moderate acid inhibition using an H 2 ‐blocker is sufficient to achieve optimal H. pylori eradication.