Premium
Helicobacter pylori eradication using a 7‐day regimen of low‐dose clarithromycin, lansoprazole and amoxycillin
Author(s) -
Lim A. G.,
Walker C.,
Chambers S.,
Gould S. R.
Publication year - 1997
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1997.00184.x
Subject(s) - lansoprazole , medicine , clarithromycin , helicobacter pylori , regimen , gastroenterology , rapid urease test , urea breath test , amoxicillin , breath test , adverse effect , metronidazole , tolerability , nausea , gastritis , antibacterial agent , antibiotics , helicobacter pylori infection , microbiology and biotechnology , biology
Aim: To evaluate the efficacy of a 7‐day regimen of clarithromycin 250 mg b.d., amoxycillin 1 g b.d., and lansoprazole 30 mg b.d. as a treatment for Helicobacter pylori infection. Methods: H. pylori status of dyspeptic patients was assessed by 13 C‐urea breath test and at endoscopy by histology, culture and rapid urease testing of gastric biopsies. Fifty‐one H. pylori ‐positive patients were treated with the above regimen. H. pylori status was reassessed by 13 C ‐urea breath test not less than 28 days after completing treatment. Adverse events and compliance were evaluated. Results: On an intention‐to‐treat basis, H. pylori infection was cured in 77% (95% CI: 65–88%) of patients. Minor side‐effects including diarrhoea, nausea and taste disturbance were reported by 64% of patients. Ninety‐five per cent of patients consumed > 95% of tablets. Metronidazole resistance was 29% but all cultures were sensitive to amoxycillin and clarithromycin. Conclusion: This 7‐day treatment with low‐dose clarithromycin was moderately effective in curing H. pylori infection. Although compliance was excellent, there was a high frequency of minor adverse events.