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Helicobacter pylori eradication using one‐week low‐dose lansoprazole plus amoxycillin and either clarithromycin or azithromycin
Author(s) -
CAMMAROTA G.,
TURSI A.,
PAPA A.,
MONTALTO M.,
VENETO G.,
CUOCO L.,
FEDELI G.,
GASBARRINI G.
Publication year - 1996
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1996.d01-533.x
Subject(s) - lansoprazole , clarithromycin , helicobacter pylori , medicine , amoxicillin , azithromycin , gastroenterology , rapid urease test , antibacterial agent , antibiotics , gastritis , microbiology and biotechnology , biology
Aim : To evaluate and compare two 1‐week low‐dose triple therapies based on lansoprazole, amoxycillin and a macrolide in eradicating Helicobacter pylori . Methods : Seventy consecutive patients, suffering from dyspeptic symptoms with H. pylori infection, were randomly allocated to one of two treatment groups: (A) (LAC; n =35) lansoprazole 30 mg once daily, amoxycillin 1000 mg b.d., clarithromycin 250 mg b.d., all for 7 days; and (B) (LAA; n =35) lansoprazole 30 mg once daily and amoxycillin 1000 mg b.d., both for 7 days, plus azithromycin 500 mg once daily for only 3 days. The H. pylori status was evaluated by means of histology and rapid urease test at entry and 8 weeks after treatment. Results : Three patients did not complete the treatment: one in the LAC group was withdrawn owing to severe side‐effects; two patients in the LAA group stopped the treatment prematurely. H. pylori eradication was obtained in 28 of 34 (82%; 95% CI=66–93%) patients in the LAC group and in 20 of 33 (61%; 95% CI=42–77%) patients in the LAA group. The difference is significant ( P <0.029). On intention‐to‐treat analysis, the rates of eradication were (28 of 35 patients, 80% in the LAC group and 20 of 35 patients, 57% in the LAA group. Side‐effects occurred in nine (26%) and six (18%) patients in the LAC and LAA groups, respectively. Conclusions : Low‐dose lansoprazole plus amoxycillin and clarithromycin is more effective than low‐dose lansoprazole plus amoxycillin and azithromycin, but it gave a greater incidence of side‐effects.