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Sucralfate and hydrocortisone enemas in the treatment of active ulcerative proctitis—a randomized single‐blind comparative study
Author(s) -
ARDIZZONE S.,
PETRILLO M.,
ANTONACCI C. M.,
BIANCHI PORRO G.
Publication year - 1996
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1996.81253000.x
Subject(s) - sucralfate , medicine , ulcerative colitis , enema , gastroenterology , proctitis , hydrocortisone , randomized controlled trial , disease
Background : Sucralfate is a non‐absorbable aluminium salt of sucrose octasulphate which in recent studies has proved to be of possible use in the treatment of active distal ulcerative colitis. Aim : The aim of this randomized, single‐blind, study was to compare 10 g sucralfate with 100 mg hydrocortisone enemas in the treatment of 40 patients (26 male and 14 female; mean age 36.5 years, range 18–65 years) with active ulcerative proctitis, twice daily for 4 weeks. Methods : A clinical, sigmoidoscopic and histological assessment was performed before and 4 weeks after the start of the therapy. Results : Both treatments showed significant within‐treatment improvement in clinical, endoscopic and histological grades (Wilcoxon's matched pair test, P <0.05). Between‐treatment comparisons, using the Mann–Whitney test, showed that hydrocortisone is more effective than sucralfate in improving the clinical score ( P <0.05). Conclusions : Sucralfate enema treatment, which was significantly less effective than hydrocortisone enemas in this study, has very limited use in the treatment of active ulcerative proctitis.