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Twenty‐four‐hour intragastric acidity following early evening or bedtime administration of roxatidine in duodenal ulcer patients
Author(s) -
LAZZARONI M.,
SANGALETTI O.,
BARGIGGIA S.,
BENSI G.,
CANALI A.,
BIANCHI PORRO G.
Publication year - 1996
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1996.716896000.x
Subject(s) - bedtime , evening , placebo , medicine , regimen , morning , oral administration , anesthesia , gastroenterology , physics , alternative medicine , pathology , astronomy
Aim : To assess the usefulness of early evening administration of roxatidine 150 mg as an alternative to the traditional bedtime regimen. Methods : Twenty‐four patients with healed duodenal ulcer were dosed according to a balanced incomplete‐block design, with two of the following regimens: placebo, roxatidine 150 mg at 07.30 h (early evening) or roxatidine 150 mg at 22.00 h (bedtime). Twenty‐four‐hour intragastric pH‐metry was started at 18.00 h on the first day of dosing. Median pH was determined for the 24‐h period, and for the following time intervals: 20.00–00.00 h, 00.00–08.00 h and 08.00–18.00 h. Percentage time in the 24‐h period with pH greater than 4.0 was also calculated. Results : The two roxatidine regimens proved significantly superior to the placebo, decreasing 24‐h acidity for all the time intervals, except the 20.00–00.00 h period, when mean intragastric pH with the early evening regimen (4.5±1.1) proved significantly higher than after placebo (2.2±1.0) or when roxatidine was taken at bedtime (2.4±1.1). Conclusion : Early evening administration of roxatidine may afford satisfactory control of 24‐h acidity, offering a useful alternative to conventional bedtime administration.