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Omeprazole versus ranitidine: short‐term triple‐therapy in patients with Helicobacter pylori ‐positive duodenal ulcers
Author(s) -
SPADACCINI A.,
DE FANIS C.,
SCIAMPA G,
MASCIULLI V,
PANTALEONE U,
DI VIRGILI M.,
MAGNARINI C.,
PIZZICANNELLA G.
Publication year - 1996
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1996.54196000.x
Subject(s) - medicine , omeprazole , ranitidine , gastroenterology , rapid urease test , helicobacter pylori , clarithromycin , tinidazole , discontinuation , duodenum , gastritis , antibiotics , metronidazole , microbiology and biotechnology , biology
Aim : To compare the results of two short triple‐therapy regimens, different only in the antisecretory drugs used, in patients with active duodenal ulcer and Helicobacter pylori infection. Methods : All patients received a combination of clarithromycin 250 mg b.d. and tinidazole 500 mg b.d. for 1 week, in addition to an antisecretory drug: omeprazole 20 mg (50 patients) or ranitidine 300 mg (50 patients) twice daily for 1 week, followed by a single daily dose for a further 3 weeks. Upper gastrointestinal endoscopy, with rapid urease test and histological examination of antral and corpus biopsies, was performed prior to the treatment and at least 2 months after the discontinuation of the antisecretory therapy. Results : Duodenal ulcer healing was documented in all patients at the endoscopic examination after therapy. H. pylori eradication was achieved in 46 of 50 patients (92%, 95% CI=85–99%) in the omeprazole group and in 43 of 50 patients (86%, 95% CI=76–96%) in the ranitidine group; the difference is not significant. Conclusion : Omeprazole or ranitidine, in combination with clarithromycin and tinidazole, are equally effective in the eradication of H. pylori infection and healing of duodenal ulcers.