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Low‐dose famotidine and ranitidine as single post‐prandial doses: a three‐period placebo‐controlled comparative trial
Author(s) -
REILLY T. G.,
SINGH S.,
COTTRELL J.,
MANN S. G.,
STAUFFER L.,
WALT R. P.
Publication year - 1996
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1996.50192000.x
Subject(s) - famotidine , medicine , ranitidine , placebo , post prandial , period (music) , randomized controlled trial , anesthesia , gastroenterology , endocrinology , diabetes mellitus , physics , alternative medicine , pathology , acoustics
Background: Low‐dose H 2 ‐receptor antagonists are available without prescription for the self‐medication of dyspepsia. Methods: To investigate the relative abilities of low doses of famotidine and ranitidine to raise intragastric pH after a single post‐prandial evening dose, 25 healthy volunteers completed a three‐period cross‐over trial of famotidine 10 mg, ranitidine elixir 75 mg and placebo. A standard meal was given at 18.30 h and drug or placebo at 19.30 h to subjects fasted for 5.5 h. Intragastric pH was recorded with nasogastric electrodes from 18.00 to 07.30 h by GastrograpH II recorder. Results: The geometric mean area under the pH–time curve for the 5–9 h post‐dose period was 1.49 pH units/h following placebo, 3.43 pH units/h following famotidine 10 mg (agent/placebo ratio 2.3; P < 0.001, ANOVA) and 2.6 pH units/h following ranitidine 75 mg (1.75; P <0.001). The geometric mean area under the pH–time curve ratio of famotidine 10 mg to ranitidine 75 mg was 1.32 ( P <0.016). Median pH over the 5–9 h period was 1.1 following placebo, 2.7 following famotidine 10 mg ( P <0.05 by comparison with placebo) and 1.9 following ranitidine 75 mg ( P <0.05); comparison of median pH showed no significant difference between the active drugs. The percentage of pH values greater than 3.0 for the period 0–12 h post‐dose was 9.7% following placebo, 30.0% following famotidine 10 mg ( P <0.05) and 24.9% following ranitidine 75 mg ( P <0.05); there was no significant difference between the active drugs. Conclusions: We conclude that both famotidine 10 mg and ranitidine 75 mg significantly raise intragastric pH when given as single post‐prandial doses. Famotidine 10 mg may have a greater effect than ranitidine elixir 75 mg over the 5–9‐h period after dosing.