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Time to maximum effect of lansoprazole on gastric pH in normal male volunteers
Author(s) -
BELL N. J. V.,
HUNT R. H.
Publication year - 1996
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.1996.103242000.x
Subject(s) - lansoprazole , dosing , medicine , pharmacokinetics , morning , oral administration , pharmacology , gastroenterology , omeprazole
Background : The time to maximum inhibition of gastric acidity resulting from repeated oral dosing with lansoprazole 30 mg daily for 7 days was studied in nine healthy male volunteers. Methods : Twenty‐four hour intragastric pH monitoring was performed before treatment and on days 1, 3, 5 and 7 of dosing with lansoprazole. Blood samples were taken for the estimation of plasma lansoprazole concentrations. Results : Lansoprazole 30 mg increased mean 24‐h intragastric pH to 3.57 on day 1 compared with baseline mean pH of 2.11 ( P <0.05). The mean intragastric pH during the morning period (08.00–13.00 h) was significantly higher on days 3, 5 and 7 than on day 1, but no consistent differences between day 1, 3, 5 and 7 were noted for subsequent periods (13.00–18.00, 18.00–21.00 and 23.00–07.00 h). There were no differences in mean pH between days 3, 5 and 7. Intragastric pH was maintained above pH 3 for 54.7, 60.1, 61.9 and 67.4% of the time on days 1, 3, 5 and 7, respectively. Lansoprazole pharmacokinetic parameters did not change with daily dosing. The area under the lansoprazole plasma concentration–time curve correlated with the intragastric pH ( P <0.005). Conclusions : Lansoprazole 30 mg raised intragastric pH significantly from baseline on day 1 to a maximum effect as early as 6 h after the first dose. The degree and duration of acid suppression confirm the usefulness of lansoprazole for the treatment of acid‐related disorders.