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Prevention of postsurgical relapse and recurrence in Crohn's disease
Author(s) -
Cottone M.,
Orlando A.,
Viscido A.,
Calabrese E.,
Cammà C,
Casà A.
Publication year - 2003
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1046/j.1365-2036.17.s2.12.x
Subject(s) - medicine , crohn's disease , disease , metronidazole , surgery , risk factor , clinical trial , gastroenterology , antibiotics , microbiology and biotechnology , biology
Summary After first resection in Crohn's disease at 1 year 60–80% of patients have endoscopic recurrence, 10–20% have clinical relapse, and 5% have surgical recurrence. 1 , 2 This review focuses on the actual evidence on the prevention of recurrence and relapse dealing with risk factors and with drugs. Smoking is the only risk factor for Crohn's disease, that has been shown to be related to both endoscopic and surgical recurrence and relapse. Among the different drugs evaluated, some (Mesalamine and Metronidazole) have been shown to be effective, whereas others (immunosuppressive) need to be evaluated in further, new trials.