Open AccessThe role of proteolysis in R gene mediated defence in plants
Author(s) -
Tör Mahmut,
Yemm Antony,
Holub Eric
Publication year - 2003
Publication title -
molecular plant pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 103
eISSN - 1364-3703
pISSN - 1464-6722
DOI - 10.1046/j.1364-3703.2003.00169.x
Subject(s) - biology , ubiquitin ligase , arabidopsis , ubiquitin , gene , gene silencing , cloning (programming) , genetics , protein degradation , microbiology and biotechnology , f box protein , proteolysis , biochemistry , mutant , enzyme , computer science , programming language
SUMMARY Within the last 10 years, numerous R genes have been cloned from natural genetic variation in model as well as crop plants, and these have been classified according to their motifs. Some of the downstream signalling components have also been identified by artificial mutagenesis. Recently, cloning of three of these signalling genes ( COI1 , RAR1 and SGT1b ) from Arabidopsis , barley and tobacco have helped uncover the physiological link between defence signalling and ubiquitin‐mediated protein degradation. The physical association of COI1 and SGT1b with the components of ubiquitin–ligase complexes has been shown. In addition, post‐transcriptional silencing of some of the subunits of the ubiquitin‐ligase complex has led to a loss of resistance, indicating that protein degradation may also act as a regulatory mechanism in plant defence. Over the next few years, we should expect to see more examples of the interplay between the defence response and protein degradation in plants.