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Evaluation of the effects of lofexidine and clonidine on naloxone‐precipitated withdrawal in opioid‐dependent humans
Author(s) -
Walsh Sharon L.,
Strain Eric C.,
Bigelow George E.
Publication year - 2003
Publication title -
addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0965-2140
DOI - 10.1046/j.1360-0443.2003.00372.x
Subject(s) - clonidine , anesthesia , heart rate , medicine , (+) naloxone , methadone , opioid , placebo , blood pressure , morphine , psychology , pharmacology , receptor , alternative medicine , pathology
Aims To examine the efficacy of lofexidine, an α 2 adrenergic agonist, to suppress opioid withdrawal symptoms in opioid‐dependent humans under in‐patient laboratory conditions by using a naloxone challenge procedure. Design Randomized, within‐subject, cross‐over design with drug administration taking place under double‐blind and triple‐dummy conditions. Setting A 14‐bed in‐patient hospital research unit dedicated to the conduct of behavioral pharmacology studies. Participants Eight healthy adult volunteers (two female/six male) with histories of polysubstance abuse and current physical dependence on opioids. Intervention Participants were stabilized onto methadone and maintained on 30 mg/day, p.o. throughout the study. Oral placebo, lofexidine (0.4, 0.8 and 1.6 mg, p.o.) and clonidine (0.1 and 0.2 mg, p.o.) were each tested as pre‐treatments once in combination with each of three intramuscular naloxone doses (0, 0.1 and 0.3 mg, i.m.) during 18 separate experimental sessions. Measurements An array of physiological indices (e.g. heart rate, blood pressure, pupil diameter) as well as a number of subjective and observer‐rating scales sensitive to opioid withdrawal effects. Findings As expected, lofexidine and clonidine both produced dose‐related decreases in blood pressure and heart rate but few subjective effects; naloxone increased opioid withdrawal signs and symptoms in a dose‐ and time‐dependent fashion. Although both lofexidine and clonidine reduced the cardiovascular response to naloxone challenge, close inspection of the data reveal that this occurred only to the extent that baseline physiological parameters were reduced, while neither drug significantly modified the overall magnitude of the response to naloxone. Moreover, neither lofexidine nor clonidine suppressed the subjective discomfort of opioid withdrawal or significantly reduced other autonomic signs of opioid withdrawal, such as lacrimation or rhinorrhea. Conclusions These data suggest that lofexidine is well tolerated even at supratherapeutic acute doses. However, its failure to modify most signs and symptoms of opioid withdrawal suggest that its effective use in spontaneous withdrawal will require concomitant medications for improved therapeutic response.