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A genetic analysis of smoking behavior in family members of older adult males
Author(s) -
Cheng Li ShuChuan,
Swan Gary E.,
Carmelli Dorit
Publication year - 2000
Publication title -
addiction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.424
H-Index - 193
eISSN - 1360-0443
pISSN - 0965-2140
DOI - 10.1046/j.1360-0443.2000.95342713.x
Subject(s) - proband , family aggregation , mendelian inheritance , family history , demography , concordance , cousin , psychology , heredity , medicine , genetic model , disease , genetics , biology , geography , archaeology , sociology , gene , mutation
Aims. To conduct a genetic study of smoking behavior in 493 three‐generation families. Design. Complex segregation analysis and maximum likelihood statistics were used to describe the familial clustering of ever‐smoking under several transmission models. Setting. The Western Collaborative Group Study, an ageing and health study currently in its 39th year of follow‐up. Participants. Probands were male participants who were of mean age 71.6 years at the time of the family history interview in 1986‐88. Measurements. Data were collected via an interview that focused on the family smoking history of participants. Smoking histories of all first‐degree relatives were obtained from probands. Findings. Evidence for genetic transmission was indicated by rejection of both the environmental and sporadic models in favor of a Mendelian genetic model with residual familial effects from spouses and both parents. Conclusions. The best‐fitting model was that of a dominant major gene with low estimated frequency and residual familial correlations. This is the first study to date to model the familial transmission of ever‐smoking in three‐generation families.