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Successful treatment of acquired haemophilia with prednisolone therapy
Author(s) -
Ali R.,
Özçelik T.,
Özkalemkaş F.,
Özkocaman V.,
Ozan Ü.,
Yalçin M.,
Saricaoğlu H.,
Tunali A.
Publication year - 2003
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1046/j.1351-8216.2003.00830.x
Subject(s) - medicine , prednisolone , coagulopathy , haemophilia , thrombosis , haemophilia a , rescue therapy , surgery , intensive care medicine
Summary. Acquired hemophilia is a rare, life threatening coagulopathy in adults caused by the development of autoantibodies against to factor VIII. No general consensus exists on the best therapeutic approach. We report here a case that presented with extensive cutaneous and mucosal bleedings due to factor VIII inhibitors and treated successfully with steroid therapy alone but complicated with a life threatening thromboembolic attack during her follow up. In conclusion, corticosteroids are “cost effective therapy” associated with high inhibitor elimination rates and although recurrence of inhibitor in a patient with factor VIII inhibitor is an expected clinical situation thrombosis risk should also be considered.