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The clinical efficacy and efficiency of a 100‐IU starting dose of recombinant follicle stimulating hormone (Puregon ® ) in Korean women undergoing in vitro fertilization and embryo transfer
Author(s) -
Moon Shin Yong,
Kim Seok Hyun,
Ku Seung Yup,
Jee Byoung Chul,
Choi Young Min,
Lee Jin Yong
Publication year - 2003
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1046/j.1341-8076.2003.00096.x
Subject(s) - medicine , controlled ovarian hyperstimulation , intracytoplasmic sperm injection , in vitro fertilisation , embryo transfer , ovarian hyperstimulation syndrome , human chorionic gonadotropin , human fertilization , andrology , embryo cryopreservation , follicle stimulating hormone , gynecology , gonadotropin , hormone , pregnancy , embryo , pregnancy rate , gestation , luteinizing hormone , biology , anatomy , genetics , microbiology and biotechnology
Aim: A prospective, non‐comparative study was conducted to evaluate the efficacy and efficiency of a starting dose of 100 IU recombinant follicle stimulating hormone (rhFSH, Puregon ® ) in women undergoing ovarian stimulation prior to in vitro fertilization (IVF). Methods: A total of 40 women were down‐regulated with gonadotropin releasing hormone agonist (long protocol), then treated with a fixed dose of 100 IU rhFSH for the first 4 days, and the dose of gonadotropin administration was adjusted according to patient's response thereafter. A maximum number of 3 embryos were transferred in 32 patients. Results: Nine patients were treated with intracytoplasmic sperm injection, and 24 with conventional IVF. The duration of stimulation was 10.8 ± 1.8 days, serum estradiol concentration on human chorionic gonadotropin day was 1693.0 ± 1651.2 pg/mL, and 1480 ± 450 IU rhFSH was used. A mean number of 8.4 ± 5.7 oocytes were retrieved, 4.9 ± 4.3 embryos obtained, 2.4 ± 0.9 embryos transferred, and 3.5 ± 3.2 embryos cryopreserved. The proportion of mature oocytes was 71.6%, and the fertilization rate was 86.4%. Clinical pregnancy was achieved in 8 patients (25.0%), and all of these pregnancies are ongoing or delivered. There were 3 cases of twin gestations (37.5%). The implantation rate was 13.1% (11/84). There was one case of moderate ovarian hyperstimulation syndrome, however, the patient recovered within 7 days without any complications. Conclusion: The starting dose of 100 IU rhFSH has a good safety profile, and is adequate in controlled ovarian hyperstimulation for IVF with a small amount of gonadotropin administered.