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A randomized controlled study of three targets of propofol plasma concentration in patients undergoing uterine dilation and curettage
Author(s) -
Uerpairojkit Ketchada,
Urusopone Pakorn,
Somboonviboon Wanna
Publication year - 2003
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1046/j.1341-8076.2003.00083.x
Subject(s) - medicine , propofol , anesthesia , bispectral index , dilation and curettage , fentanyl , curettage , nitrous oxide , surgery , pregnancy , abortion , biology , genetics
Aim: To compare the efficacy and the complications of three target levels of propofol plasma concentration in patients undergoing uterine dilation and curettage. Methods: Sixty‐nine patients were randomly allocated to receive propofol target controlled infusion at different target concentrations of 4 (group I), 5 (group II) and 6 (group III) mcg/mL combined with 1 µg/kg of fentanyl and 66% of nitrous oxide. Patients’ movement during the procedure, hemodynamic variables, oxygen saturation, end tidal carbon dioxide, time to sleep and awake, and bispectral index score were recorded. Results: Seven patients in group I, one in group II, and none in group III ( P < 0.05) moved grossly during the procedure. More patients in group III developed hypotension (5 vs 0 and 2 in group I and II, P < 0.05), but no difference was found regarding respiratory complication. No difference was found in time to sleep, but time to wake was longer in group III. Conclusion: Propofol infusion at the target concentration of 5 µg/mL was recommended for uterine dilation and curettage when it was administered with fentanyl 1 µg/kg and nitrous oxide 66% under close monitoring and appropriate respiratory management.