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Immunohistochemical Study of Steroid Sulfatase in Minimal Deviation Adenocarcinoma of the Uterine Cervix
Author(s) -
Ohtsuka Yukiko,
Toma Yoshiro,
Saito Hiroshi,
Yanaihara Atsushi,
Yokoyama Kazuhiko,
Ichizuka Kiyotake,
Suzuki Akira,
OKAI Takashi,
Kushima Miki
Publication year - 2002
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1046/j.1341-8076.2002.t01-3-00011.x
Subject(s) - immunohistochemistry , medicine , pathology , endocervix , mucin , estrogen receptor , cervix , steroid sulfatase , adenocarcinoma , malignancy , progesterone receptor , cancer , hormone , steroid , breast cancer
Objective: Minimal deviation adenocarcinoma of the uterine cervix (adenoma malignum : MDA) is a unique neoplasm whose prognosis is poor in spite of the deceptively benign appearance of the tumor cells. The pathogenesis of MDA is unknown. To gain a better understanding of its pathogenesis, the present study was undertaken to explore the immunohistochemical expression of steroid sulfatase (STS), steroid receptors and gastric mucin in MDA and the expression was compared with that in non‐neoplastic cervical glands (NC) and pyloric glands(PG). Methods: Histopathological specimens of MDA (typical lesion n = 3, less well‐differentiated lesion n = 1) obtained at gynecological operation were subjected and the immunohistochemical staining for STS, estrogen receptor (ER), progesterone receptor (PR) and gastric mucin was performed. NC tissue (n = 5) and PG (n = 2) were also subjected. Results: The expression of STS was found in all cases of MDA with a typical lesions, but not in a less well‐differentiated cases. All cases of MDA expressed strong staining for gastric mucin. On the other hand, they did not show ER or PR staining. NC expressed positive staining for STS, ER and PR, but not for gastric mucin. PG strongly expressed gastric mucin, but ER, PR and STS did not. Conclusions: The immunohistochemical expression of STS in typical lesions indicates that MDA partially retained the characteristics of the cervical gland with regulational function of steroid hormones. This suggests that MDA might be malignancy transformed not from ectopic gastric mucosa, but from the endocervical gland by way of gastric metaplasia.