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Placental protein 17b overexpression in human uterine cervical cancer
Author(s) -
Than Gábor N.,
Sümegi Balázs,
Szekeres György,
Bellyei Szabolcs,
Than Nándor G.,
Szigeti Andras,
Bohn Hans
Publication year - 2002
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1046/j.1341-8076.2002.00003.x
Subject(s) - medicine , cervical cancer , cervical carcinoma , hela , apoptosis , cervical intraepithelial neoplasia , epithelium , basal (medicine) , cancer research , basal cell , pathology , cell , oncology , cancer , biology , biochemistry , genetics , insulin
We found overexpression of placental protein 17b (PP17b), cloned by us, in human squamous cervical carcinomas. Patients’ PP17b serum levels were elevated and declined after surgery. Healthy cervical epithelium was PP17 negative; in cervical intraepithelial neoplasia and carcinoma, basal‐type cells were negative, but squamous‐type cells were positive, for PP17. In HeLa cells, expression of PP17b correlated with cell differentiation and apoptosis.