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Evidence for an intrarenal renin‐angiotensin system in the European lesser‐spotted dogfish
Author(s) -
Wells A.,
Anderson W. G.,
Hazon N.
Publication year - 2003
Publication title -
journal of fish biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.672
H-Index - 115
eISSN - 1095-8649
pISSN - 0022-1112
DOI - 10.1046/j.1095-8649.2003.00234.x
Subject(s) - scyliorhinus canicula , biology , renin–angiotensin system , endocrinology , medicine , captopril , diuresis , excretion , kidney , fishery , blood pressure , fish <actinopterygii>
The existence of an intrarenal renin‐angiotensin system (RAS) in a perfused European lesser‐spotted dogfish Scyliorhinus canicula trunk preparation was examined by the inhibition of angiotensin‐converting enzyme by captopril. This resulted in a glomerular diuresis, an increase in urea and chloride clearance and excretion, and an increase in transport maxima for glucose. It is proposed that these results suggest the presence of an intrarenal RAS.