Premium
Cardiovascular Risk Factors in Subjects with Helicobacter pylori Infection
Author(s) -
Takashima Toshiharu,
Adachi Kyoichi,
Kawamura Akira,
Yuki Mika,
Fujishiro Hirofumi,
Rumi Mohammad Azharul Karim,
Ishihara Shunji,
Watanabe Makoto,
Kinoshita Yoshikazu
Publication year - 2002
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1046/j.1083-4389.2002.00064.x
Subject(s) - medicine , helicobacter pylori , body mass index , confounding , blood pressure , triglyceride , high density lipoprotein , helicobacter pylori infection , hemoglobin , gastroenterology , cholesterol , immunology
Background. It has been proposed that Helicobacter pylori infection is related to cardiovascular disease, although this has not been fully investigated. The aim of this study was to investigate whether H. pylori in‐fection is associated with cardiovascular risk factors. Subjects and Methods. One thousand six hundred and fifty people undergoing annual medical checks at Shimane Institute of Health Science between September 1998 and August 1999 were enrolled. Gender, age, body mass index, habitual smoking and drinking, systolic and diastolic blood pressure, serum level of total cholesterol, triglyceride, high‐density lipoprotein cholesterol (HDLC), blood glucose, leukocyte count and hemoglobin were compared between H. pylori seropositive and seronegative cases. Results. In H. pylori seropositive individuals, HDLC was significantly lower than that in seronegative individuals. After adjustment for possible confounding factors (gender, age, BMI, smoking and drinking habits), mean HDLC in H. pylori ‐seropositive and seronegative individuals were 56.1 and 58.2 mg/dl, respectively ( p < .005). The percentage of the elderly (over 50 years old) individuals with HDLC < 35 mg/dl in H. pylori seropositive and seronegative groups were 7.4% and 4.7%, respectively ( p < .001). In addition, the lower HDLC level was accompanied by an increased leukocyte count. Conclusion. Long‐term infection with H. pylori may have an important role in decreasing the serum HDLC concentration.