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Developmental variation in epidermal growth factor receptor size and localization in the malaria mosquito, Anopheles gambiae
Author(s) -
Lycett G.,
Blass C.,
Louis C.
Publication year - 2001
Publication title -
insect molecular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.955
H-Index - 93
eISSN - 1365-2583
pISSN - 0962-1075
DOI - 10.1046/j.0962-1075.2001.00302.x
Subject(s) - anopheles gambiae , biology , malaria , gene , epidermal growth factor receptor , anopheles , genetics , copy number variation , receptor tyrosine kinase , microbiology and biotechnology , receptor , genome , immunology
The AGER gene encoding the epidermal growth factor receptor (EGFR) of the malaria mosquito Anopheles gambiae was cloned and sequenced. It represents a canonical member of this family of tyrosine kinase proteins exhibiting many similarities to orthologues from other species, both on the level of genomic organization and protein structure. The mRNA can be detected throughout development. Western analysis with an antibody raised against the extracellular domain of the mosquito protein suggests developmental variation in protein size and location that may be involved in the function of EGFR in the mosquito.