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Crown–rump lengths in missed miscarriages and trisomy 21
Author(s) -
Ginsberg N. A.,
Strom C.,
Verlinsky Y.
Publication year - 2001
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.0960-7692.2001.00571.x
Subject(s) - crown rump length , medicine , trisomy , miscarriage , obstetrics , gynecology , products of conception , etiology , fetus , population , pregnancy , rump , abortion , biology , pathology , anatomy , first trimester , environmental health , genetics
Objectives To compare crown–rump lengths with karyotypes of missed miscarried fetuses and to determine a relationship between crown–rump length and trisomy 21. Study design Chorionic villus sampling was performed on 129 consecutive missed miscarriages between 10 and 12 weeks by last menstrual period in patients ≥ 35 years of age. Crown–rump length was correlated with the karyotype. Statistical analysis was performed using Student's t ‐test. Results Twenty‐one of 129 missed miscarriages involved fetuses affected by trisomy 21. The crown–rump length was < 22 mm in 77% of missed miscarriages. Using a crown–rump length of ≥ 22 mm for the prediction of trisomy 21 had a sensitivity of 86%, specificity of 89%, positive predictive value of 60% and negative predictive value of 97%. At 10–12 weeks, the crown–rump lengths of missed miscarried fetuses with trisomy 21 was significantly larger ( P ≤ 0.0001) than that of the population average of missed miscarried fetuses. Conclusion In women ≥ 35 years of age, with a missed miscarriage, in whom pregnancies reached ≥ 10 weeks from the last menstrual period, a fetal crown–rump length of ≥ 22 mm has a high probability that the etiology of the loss will be secondary to trisomy 21. Copyright © 2001 International Society of Ultrasound in Obstetrics and Gynecology