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Sebaceous adenitis in the Akita: clinical observations, histopathology and heredity
Author(s) -
Reichler Iris M.,
Hauser Beat,
Schiller Irene,
Dunstan Robert W.,
Credille Kelly M.,
Binder Heinrich,
Glaus Toni,
Arnold Susi
Publication year - 2001
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1046/j.0959-4493.2001.00251.x
Subject(s) - histopathology , sebaceous gland , adenitis , medicine , dermatology , pathology , heredity , biology , genetics
Ninety‐seven pure‐bred Akitas were examined clinically and histologically for sebaceous adenitis. The diagnosis was established histologically in 23 Akitas by demonstrating an inflammatory reaction targeted against the sebaceous glands or a reduction in the number of glands. The clinical course of sebaceous adenitis in the Akita was similar to that seen in other breeds. The first skin lesions occurred mainly on the dorsal midline and ears. Compared with the Poodle, the age at first onset of the disease was more variable and the hair loss affected mainly the undercoat. The progression of sebaceous gland destruction varied between dogs and was not seen in all cases. Because bud‐like sebaceous gland proliferation could be identified, it seems that regeneration of the sebaceous glands may occur. An autosomal recessive inheritance appears to be possible. Apart from a genetic background, immune‐mediated factors possibly influence the onset and course of sebaceous adenitis.