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Circadian activity rhythm in methamphetamine‐treated Clock mutant mice
Author(s) -
Masubuchi Satoru,
Honma Sato,
Abe Hiroshi,
Nakamura Wataru,
Honma Kenichi
Publication year - 2001
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1046/j.0953-816x.2001.01749.x
Subject(s) - circadian rhythm , suprachiasmatic nucleus , rhythm , light effects on circadian rhythm , clock , circadian clock , biology , period (music) , mutant , neuroscience , darkness , medicine , endocrinology , gene , genetics , physics , botany , acoustics
It is well established that the Clock gene is essential for expressing circadian activity rhythms in mammals under constant darkness. The Clock gene product is a positive component of a molecular feedback loop which is assumed to generate the circadian rhythm. On the other hand, chronic treatment of methamphetamine (MAP) induces locomotor activity rhythm in a circadian domain, which is independent of the suprachiasmatic nucleus (SCN) and is driven by a pacemaker outside the SCN. However, it is not known whether the pacemaker outside the SCN possesses a similar molecular mechanism to that in the SCN. Here we show that MAP restores locomotor activity rhythm in arrhythmic homozygous Clock mutant ( Clock / Clock ) mice under constant darkness. This result indicates that the Clock mutation does not affect the MAP‐induced locomotor rhythm.