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Scaffolding proteins organize multimolecular protein complexes for sensory signal transduction
Author(s) -
Huber Armin
Publication year - 2001
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1046/j.0953-816x.2001.01704.x
Subject(s) - scaffold protein , mechanosensitive channels , visual phototransduction , signal transduction , biology , microbiology and biotechnology , multiprotein complex , neuroscience , transduction (biophysics) , sensory system , receptor , ion channel , retina , biophysics , biochemistry , gene
Scaffolding proteins composed of protein–protein interaction domains have emerged as organizers of multiprotein complexes in diverse cellular compartments, including neuronal synapses, cell–cell junctions of epithelial cells, and the stimulus perceiving structures of sensory neurons. This review focuses on the INAD‐assembled signalling complex of Drosophila photoreceptors, which organizes key components of the phototransduction cascade into a multiprotein signal transduction unit. The structure, the physiological consequences, and the assembly and targeting of the members of the INAD signalling complex will be described. In addition, the existence of signalling complexes in vertebrate photoreceptors, olfactory neurons and mechanosensitive hair cells will be discussed.