Premium
Lowering the extracellular potassium concentration elicits epileptic activity in neocortical tissue of epileptic patients
Author(s) -
Gorji Ali,
Köhling Rüdiger,
Straub Heidrun,
Höhling JörgMichael,
Madeja Michael
Publication year - 2001
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1046/j.0953-816x.2000.01417.x
Subject(s) - epilepsy , extracellular , potassium , neuroscience , epileptic seizure , neocortex , chemistry , psychology , biochemistry , organic chemistry
The increase in the extracellular potassium concentration ([K + ] o ) is a well‐established model of epilepsy (the so‐called high potassium model). Therefore, it is generally accepted that for the prevention of abnormal excitability and seizure generation, increases of [K + ] o must be avoided. In this paper, however, we show that on the contrary, a reduction of [K + ] o also elicits epileptic activity in brain slices of man.