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Combined effect of clarithromycin and imipenem/cilastatin against urinary biofilm infection after pyeloplasty
Author(s) -
FURUHATA MASAYUKI,
IWAMURA MASATSUGU,
BABA SHIRO,
INOUE MATSUHISA
Publication year - 2003
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1046/j.0919-8172.2003.00598.x
Subject(s) - medicine , cilastatin , imipenem/cilastatin , imipenem , pyuria , urinary system , meropenem , clarithromycin , staphylococcus epidermidis , surgery , urology , antibiotics , microbiology and biotechnology , staphylococcus aureus , biology , helicobacter pylori , genetics , antibiotic resistance , bacteria
The present report concerns a 38‐year‐old man, who had been treated with pyeloplasty and lithotomy for the improvement of urinary excretion and resolution of a kidney stone. The patient developed a biofilm infection involving Pseudomonas aeruginosa and Staphylococcus epidermidis , and had been suffering from recurrent acute pyelonephritis for one year. Combination therapy with clarithromycin (CAM) and imipenem/cilastatin (IMP/CS) consisted of administration of CAM at a dose of 400 mg/day for 1 week, followed by 500 mg/day of IMP by intravenous infusion combined with CAM (400 mg/day) for 5 days. This therapy produced an immediate antimicrobial effect and no further signs of pyuria have been seen during one year of follow‐up in this patient.