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Expression of ICAM‐1 and E‐selectin in gingival tissues of smokers and non‐smokers with periodontitis
Author(s) -
Rezavandi K.,
Palmer R. M.,
Odell E. W.E. W.,
Scott D. A.,
Wilson R. F.
Publication year - 2002
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1046/j.0904-2512.2001.joptest.doc.x
Subject(s) - periodontitis , icam 1 , medicine , intercellular adhesion molecule 1 , inflammation , immunohistochemistry , intercellular adhesion molecule , vascularity , von willebrand factor , e selectin , pathology , cell adhesion molecule , adhesion , immunology , cell adhesion , platelet , chemistry , organic chemistry
Background: Tobacco smoking affects systemic concentrations of soluble intercellular adhesion molecule (ICAM)‐1, but its effect on local expression of adhesion molecules in gingival tissue has not been studied previously. Methods: E‐selectin and ICAM‐1 expression on small blood vessel endothelia in gingival biopsies obtained from smokers ( n =17) and non‐smokers ( n =17) with periodontitis was examined with immunohistochemistry. Blood vessels were identified with monoclonal antibody for von Willebrand's factor. Results: A significantly larger number of vessels were observed in inflamed tissues of non‐smokers than smokers ( P <0.05). The number and proportion of vessels expressing both ICAM‐1 and E‐selectin was greater in sites with inflammation compared to non‐inflamed sites in both smokers and non‐smokers ( P <0.05). The proportion of the total number of vessels expressing ICAM‐1 in non‐inflamed sites was greater in non‐smokers compared with smokers ( P <0.05). Conclusions: These results suggest that the inflammatory response in smokers with periodontitis may not be accompanied by an equivalent increase in vascularity. Reduced ICAM‐1 expression in non‐inflamed areas of smokers could reflect a systemic effect of tobacco smoking on ICAM‐1 independent of inflammation.