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Effect of tempol (4‐hydroxy tempo) on gentamicin‐induced nephrotoxicity in rats
Author(s) -
Karataş Yusuf,
Seçilmiş M. Ata,
Karayaylalı İbrahim,
Doran Figen,
Büyükafşar Kansu,
Şingirik Ergin,
Saglıker Yahya,
Dikmen Atilla
Publication year - 2004
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1046/j.0767-3981.2003.00211.x
Subject(s) - gentamicin , nephrotoxicity , creatinine , blood urea nitrogen , aminoglycoside , medicine , renal function , urology , urine , pharmacology , chemistry , kidney , endocrinology , antibiotics , biochemistry
We investigated the effects of tempol (4‐hydroxy tempo), a membrane‐permeable radical scavenger, on gentamicin‐induced renal failure in rats. The rats were given gentamicin (100 mg/kg/day, i.p., once a day); and gentamicin (100 mg/kg/day, i.p.) and tempol (3.5, 7 or 14 mg/kg/day, i.p., once a day). At the end of 7 days, the gentamicin group produced the remarkable nephrotoxicity, characterized by a significantly decreased creatinine clearance and increased serum creatinine, blood urea nitrogen (BUN) and daily urine volume when compared with controls. In control the BUN value was 21.2 ± 0.07 (mg/100 mL); in comparison, it was 96.9 ± 6.03 in gentamicin group ( P < 0.05). Renal histopathologic examination confirmed acute tubular necrosis in this group. In rats treated with gentamicin and tempol a partial improvement in biochemical and histologic parameters was observed. BUN values were 96.9 ± 6.03 and 36.3 ± 2.39 in gentamicin, and gentamicin plus tempol (14 mg/kg) treated groups, respectively ( P < 0.05). These results suggest that the administration of tempol may have a protective effect on gentamicin‐induced nephrotoxicity in rats.