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Management of Helicobacter pylori eradication – the influence of structured counselling and follow‐up
Author(s) -
AlEidan F. A.,
McElnay J. C.,
Scott M. G.,
McConnell J. B.
Publication year - 2002
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.0306-5251.2001.01531.x
Subject(s) - medicine , lansoprazole , helicobacter pylori , clarithromycin , regimen , amoxicillin , gastroenterology , rapid urease test , gastritis , pharmacist , pharmacy , antibiotics , family medicine , microbiology and biotechnology , biology
Aims Helicobacter pylori ( H. pylori ) eradication rate varies according to the treatment regimen used and other factors, e.g. antimicrobial resistance and patient compliance. The aim of the present study was to evaluate the influence of patient counselling and follow‐up on H. pylori eradication rates and to document the effectiveness of a 1 week eradication regimen consisting of lansoprazole (30 mg once daily), amoxicillin (1 g twice daily) and clarithromycin (500 mg twice daily). Methods Seventy‐six dyspeptic patients, who at endoscopy were found to have gastritis, duodenitis or ulceration, and a positive H. pylori urease test, were recruited. Patients were randomly assigned to an intervention group ( n = 38) or a control group ( n = 38). Intervention patients received their medicines via the hospital pharmacy and were counselled (and followed up) by a hospital pharmacist. Control patients were given a standard advice sheet and referred to their GP who prescribed the same therapy. Results Intervention patients exhibited a statistically significant improvement in the H. pylori eradication rate (94.7% vs 73.7%; P = 0.02) and compliance (92.1% vs 23.7; P < 0.001). Of the 64 H. pylori eradicated patients, 62 were able to eliminate their antisecretory medication compared with only 12 of the H. pylori persistent patients ( P < 0.001). A pharmacoeconomic evaluation indicated that counselling and follow‐up reduced the direct costs of eradication by approximately £30 per patient. Conclusions Structured patient counselling and follow‐up can have a significant effect on H. pylori eradication rates and should be a routine part of therapy.