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Statins and the risk of idiopathic venous thromboembolism
Author(s) -
Yang ChenChang,
Jick Susan S.,
Jick Hershel
Publication year - 2002
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.0306-5251.2001.01523.x
Subject(s) - medicine , statin , venous thromboembolism , population , thrombosis , environmental health
Aims To evaluate the association between current statin use and the risk of idiopathic venous thromboembolism (VTE). Methods A population‐based retrospective follow‐up with a nested case‐control analysis using the General Practice Research Database. Results There were 72 cases of idiopathic VTE. Using normolipidaemic nonuse as the reference group, the adjusted relative risks for idiopathic VTE for current/recent statin use, past statin use, past other lipid‐lowering drug use, and hyperlipidaemic nonuse were 0.8 (0.3, 2.7), 2.4 (0.6, 10.0), 1.8 (0.4, 7.4), and 0.9 (0.4, 2.0) in the follow‐up analysis, and were 1.1 (0.3, 4.3), 3.7 (0.6, 24.1), 2.0 (0.3, 11.6), and 0.4 (0.2, 1.2) in the case‐control analysis. Conclusions Current statin use was not associated with a reduced risk of idiopathic VTE.