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Effect of bile acids on absorption of nitrendipine in healthy subjects
Author(s) -
Sasaki Masato,
Maeda Akira,
Sakamoto Koichi,
Fujimura Akio
Publication year - 2001
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.0306-5251.2001.01489.x
Subject(s) - nitrendipine , ursodeoxycholic acid , chenodeoxycholic acid , medicine , absorption (acoustics) , pharmacokinetics , bile acid , chemistry , endocrinology , calcium , pharmacology , physics , acoustics
Aims To examine whether bile acids such as ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) can influence the absorption of nitrendipine, a highly lipophilic calcium channel blocker. Methods Six healthy subjects received nitrendipine (10 mg) with and without UDCA (50 mg) and CDCA (200 and 600 mg) with an interval of 1∼2 weeks between study phases. Results Bile acids decreased the C max (ng ml −1 ) [control 10.9 ± 5.8 (mean± s.d.), UDCA 5.0 ± 4.7 (95% confidence interval for difference; 3.9, 7.8, P = 0.0006), CDCA (600 mg) 5.0 ± 3.9 (2.6, 9.2, P = 0.0059)] and AUC (ng ml −1 h) [(control; 60 ± 36, UDCA 15 ± 13 (20, 73, P = 0.0064), CDCA (600 mg) 19 ± 19 (21, 63, P = 0.0038)] of nitrendipine, while elimination half‐life remained unchanged. Conclusions These results suggest that the amount of nitrendipine absorbed was decreased when the drug was administered with UDCA and CDCA.