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Recovery of platelet function after discontinuation of clopidogrel treatment in healthy volunteers
Author(s) -
Weber ArturAron,
Braun Marina,
Hohlfeld Thomas,
Schwippert Barbara,
Tschöpe Diethelm,
Schrör Karsten
Publication year - 2001
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.0306-5251.2001.01453.x
Subject(s) - clopidogrel , discontinuation , platelet , medicine , adenosine diphosphate , pharmacology , ticlopidine , aspirin , platelet aggregation
Aims To study the recovery of platelet function after discontinuation of clopidogrel treatment in healthy volunteers. Methods Ten healthy volunteers were treated with clopidogrel (75 mg day −1 ) for 7 days. CD62P expression and PAC‐1 binding were measured by flow cytometry. Results Adenosine diphosphate (ADP, 30 µ M )‐induced platelet responses were almost completely inhibited by clopidogrel. After discontinuation of the drug, platelet function gradually increased and complete recovery was seen 7 days after the last clopidogrel dose. The mean difference (95% CI) for ADP‐induced PAC‐1 binding (fluorescence intensity) between baseline and 7 days after the last dose was 0.01 (0.61, −0.59). Single cell analysis provides direct evidence for an irreversible mode of action of clopidogrel. Conclusions This is the first report to directly demonstrate irreversibility of clopidogrel action in humans.