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Effect of acid secretion blockade by omeprazole on the relative bioavailability of orally administered furazolidone in healthy volunteers
Author(s) -
Calafatti Silvana A.,
Ortiz Rodrigo A. M.,
Deguer Maristela,
Martinez Márcio,
Pedrazzoli José
Publication year - 2001
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.0306-5251.2001.01435.x
Subject(s) - omeprazole , bioavailability , furazolidone , pharmacokinetics , crossover study , pharmacology , oral administration , bioequivalence , absorption (acoustics) , medicine , chemistry , antibiotics , biochemistry , physics , alternative medicine , pathology , acoustics , placebo
Aims The administration of omeprazole may interfere with the absorption of orally administered drugs by reducing gastric pH and hence tablet dissolution. The aim of this study was to investigate the effects of a 5 day administration of omeprazole on the pharmacokinetics of furazolidone. Methods Eighteen healthy (nine male and nine female) volunteers were selected. The study had an open randomized two‐period crossover design with a 21 day washout period between the phases. Serum concentrations of furazolidone were measured by reversed‐phase h.p.l.c. with ultraviolet detection. Results Administration of omeprazole caused a significant reduction of C max [0.34 µg ml −1 (range 0.25–0.43) vs 0.24 µg ml −1 (range 0.15–0.34)] with no significant delay in absorption t max [2.5 h (range 1.85–3.0) vs 2.4 h (range 2.06–2.71)]. Conclusions Furazolidone was rapidly absorbed after oral administration. Short‐term treatment with omeprazole did alter the relative bioavailability of this drug, probably through an effect on absorption kinetics or first‐pass metabolism.