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A double masked placebo controlled study on the effect of nifedipine on optic nerve blood flow and visual field function in patients with open angle glaucoma
Author(s) -
Rainer Georg,
Kiss Barbara,
Dallinger Susanne,
Findl Oliver,
Georgopoulos Michael,
Vass Clemens,
Menapace Rupert,
Polak Kaija,
Eichler HansGeorg,
Wolzt Michael,
Schmetterer Leopold
Publication year - 2001
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1046/j.0306-5251.2001.01432.x
Subject(s) - nifedipine , placebo , glaucoma , medicine , open angle glaucoma , visual field , ophthalmology , anesthesia , ocular hypertension , optic nerve , perfusion , blood flow , alternative medicine , pathology , calcium
Aims To investigate whether nifedipine affects ocular perfusion or visual fields in open angle glaucoma patients. Methods In a parallel group study nifedipine or placebo was administered for 3 months ( n = 30). Ocular fundus pulsation amplitude (FPA), cup blood flow (Flow cup ) and visual field mean deviation (MD) were measured. Results Five patients receiving nifedipine discontinued due to adverse events. Nifedipine did not affect FPA [difference: 0.3 µm (95% CI −0.3,0.9); P = 0.70], Flow cup : [difference: −9 rel.units (95% CI −133,114); P = 0.99], or MD [difference: 0.2dB (95% CI −2.2,2.7); P = 0.51] vs placebo. Conclusions Systemic nifedipine is not well tolerated in glaucoma patients and exerts no effect on visual fields or ocular perfusion.