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The immunohistochemical distribution of vimentin in human temporomandibular joint samples
Author(s) -
Yoshida H.,
Fukumura Y.,
Nishida M.,
Fujita S.,
Iizuka T.
Publication year - 2004
Publication title -
journal of oral rehabilitation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 93
eISSN - 1365-2842
pISSN - 0305-182X
DOI - 10.1046/j.0305-182x.2003.01215.x
Subject(s) - vimentin , immunohistochemistry , synovial membrane , pathology , connective tissue , temporomandibular joint , medicine , arthritis , immunology
summary The aim of this investigation was to evaluate the immunohistochemical distribution of vimentin in the temporomandibular joint (TMJ) and to compare it with the control specimens. Immunohistochemical distribution in the disc and synovial membrane in 30 human TMJ (internal derangement of TMJ, n = 20; and control, n = 10) was studied immunohistologically using paraffin‐embedded tissue and specific anti‐human vimentin monoclonal antibody. Vimentin expression was distributed in chondrocyte‐like cells, synovial cells and endothelial cells. There was an obvious distinction of vimentin immunoreactivity between the control specimens and internal derangement cases, in the posterior and/or anterior loose connective tissues. In particular, intensive vimentin expression was detected in the hypertrophic synovial membrane of internal derangement cases. The findings of the present study suggest that vimentin might be an important marker of pathological hypertrophy of the synovial membrane and/or connective tissue with internal derangement of TMJ.