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Antigen‐presenting cells and tolerance induction
Author(s) -
Von Bubnoff D.,
De La Salle H.,
Weßendorf J.,
Koch S.,
Hanau D.,
Bieber T.
Publication year - 2002
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1046/j.0105-4538.2001.00001.x-i4
Subject(s) - antigen , immunology , immune system , immune tolerance , organism , self tolerance , biology , antigen presenting cell , t cell , microbiology and biotechnology , medicine , genetics
T cell tolerance induction to foreign and self‐antigens has occupied research since the beginning of the understanding of the immune system. Much controversy still exists on this question even though new methods became available to investigate immunoregulatory mechanisms. Antigen‐presenting cells play a pivotal role in transferring information from the periphery of the organism to lymphoid organs. There, they initiate not only the activation of naive T cells but seem to deliver important signals which result in T cell unresponsiveness with antigen‐specific tolerance induction.