Premium
A new insight into aspirin‐induced asthma
Author(s) -
Jawien J.
Publication year - 2002
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.0014-2972.2001.00954.x
Subject(s) - aspirin , asthma , cyclooxygenase , arachidonic acid , medicine , arachidonic acid metabolism , nonsteroidal , pharmacology , chemistry , immunology , biochemistry , enzyme
In about 10% of adult patients with asthma, aspirin and other nonsteroidal anti‐inflammatory drugs precipitate attacks of dyspnoea. Accumulated evidence shows that these reactions are due to the interference of aspirin‐like drugs with arachidonic acid metabolism in the lungs of the sensitive patients: inhibition of cyclooxygenase is accompanied by overproduction of cysteinyl leukotrienes. The mechanisms of these reactions and the characteristic course of aspirin‐induced asthma and its management are discussed.