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Severe decrease in peripheral blood dendritic cells in hairy cell leukaemia
Author(s) -
BourguinPlonquet Anne,
Rouard Hélène,
RoudotThoraval Françoise,
Bellanger Coralie,
Marquet Jeanine,
DelfauLarue MarieHélène,
Diviné Marine,
Farcet JeanPierre
Publication year - 2002
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1046/j.0007-1048.2001.03318.x
Subject(s) - immunology , flow cytometry , myeloid , immune system , dendritic cell , intracellular , antigen , acquired immune system , antigen presentation , monocyte , t cell , medicine , biology , microbiology and biotechnology
Summary. Clinical studies in hairy cell leukaemia (HCL) have linked the frequent occurrence of infections due to intracellular pathogens and a profound monocytopenia. More recently, dendritic cells (DC), a subset of which are related to monocytes, were shown to be the professional antigen‐presenting cells which stimulate the adaptive immune response. Using membrane markers and flow cytometry, we determined in peripheral blood whether various DC subsets and monocytes were impaired in HCL. Lymphoid and myeloid DC were virtually absent in five HCL patients with active disease. After treatment, both DC and monocytes recovered slowly. The decrease in DC suggests that defective antigen presentation could affect susceptibility to intracellular pathogens in HCL.